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Table 2 Parameter set - parameters of the simulation.

From: Modeling lymphocyte homing and encounters in lymph nodes

PARAMETER SYMBOL MEANING RANGE VALUE (UNITS) REF.
KNOWN VALUES
DupStepB d B B's duplication steps N 4 [34]
DupStepTH d TH TH's duplication steps N 4 [34]
VelocityB v B B cells' velocity R 6 μ m/min [27, 28]
VelocityTH v TH TH's velocity R 11 μ m/min [27, 28]
VelocityDC v DC DCs' velocity R 3 μ m/min [25]
DiffCoeff D chemokines' diffusion coeff. R 3·103 μ m2/min [27, 28]
HalfLife λ chemokines' half life R 3 hrs [25, 26]
NInitial [B] B(0) B's initials per μ l N 105 (cells/μ l) [5, 31]
NInitial [TH] TH(0) TH's initials per μ l N 2·105 (cells/μ l) [5, 31]
NInitial [DC] DC(0) DC's initials per μ l N 103 (cells/μ l) [5, 31]
NCELLS_B_ENTRY f B incoming flux of TH cells N 31 cells/min [5]
NCELLS_TH_ENTRY f TH incoming flux of TH cells N 190 cells/min [5]
ARBITRARY PARAMETERS
NBITSTR l bit-string length N 22 (*) -
pDCAg p DC DC affinity to Ag (prob) [0, 1] 0.04 -
nHEV n HEV numbers of HEV per μ l N 4 (μ l-1) [30]
pExit p Exit exit prob for cells [0, 1] 0.44 -
ChemQty q released chemokines qty R 108 mol (min src)-1 [35]
INITIAL CONDITIONS
microL mL volume N 10 (μ l) -
deltaT Δt time resolution R 30 (min) -
nSteps T time steps of the simulation N 500 (steps) -
AgInjFreq f Ag injection freq. of soluble Ags N 4 (day-1) -
AgInjQty n Ag soluble Ags per injection N 100 -
  1. Values that are taken from literature are provided with references. N and R indicate integer and real numbers respectively. (*) This choice of the bit string length represents a tradeoff between the computational cost of the simulation and the variability required for a realistic description of receptors repertoire.