Table 2 Parameter set - parameters of the simulation.

KNOWN VALUES

DupStepB

d _B

B's duplication steps

N

4

[34]

DupStepTH

d _TH

TH's duplication steps

N

4

[34]

VelocityB

v _B

B cells' velocity

R

6 μ m/min

[27, 28]

VelocityTH

v _TH

TH's velocity

R

11 μ m/min

[27, 28]

VelocityDC

v _DC

DCs' velocity

R

3 μ m/min

[25]

DiffCoeff

D

chemokines' diffusion coeff.

R

3·10³ μ m²/min

[27, 28]

HalfLife

λ

chemokines' half life

R

3 hrs

[25, 26]

NInitial [B]

B(0)

B's initials per μ l

N

10⁵ (cells/μ l)

[5, 31]

NInitial [TH]

TH(0)

TH's initials per μ l

N

2·10⁵ (cells/μ l)

[5, 31]

NInitial [DC]

DC(0)

DC's initials per μ l

N

10³ (cells/μ l)

[5, 31]

NCELLS_B_ENTRY

f _B

incoming flux of TH cells

N

31 cells/min

[5]

NCELLS_TH_ENTRY

f _TH

incoming flux of TH cells

N

190 cells/min

[5]

ARBITRARY PARAMETERS

NBITSTR

l

bit-string length

N

22 (*)

-

pDCAg

p _DC

DC affinity to Ag (prob)

[0, 1]

0.04

-

nHEV

n _HEV

numbers of HEV per μ l

N

4 (μ l^-1)

[30]

pExit

p _Exit

exit prob for cells

[0, 1]

0.44

-

ChemQty

q

released chemokines qty

R

10⁸ mol (min src)^-1

[35]

INITIAL CONDITIONS

microL

mL

volume

N

10 (μ l)

-

deltaT

Δt

time resolution

R

30 (min)

-

nSteps

T

time steps of the simulation

N

500 (steps)

-

AgInjFreq

f _Ag

injection freq. of soluble Ags

N

4 (day^-1)

-

AgInjQty

n _Ag

soluble Ags per injection

N

100

-