Figure 1From: Uncovering transcriptional interactions via an adaptive fuzzy logic approachConceptual diagram of the AdaFuzzy algorithm. First, consensus sequence motifs of a given TF are identified using a robust PWM (rPWM), which the rPWM is then used to search for potential TF binding sites in the upstream sequence of a given target gene via a vector of three features. Then this feature vector is incorporated to predict potential TIs by an adaptive fuzzy system (ANFIS), and a classifier is developed to infer the interaction types (AT or RT). Finally, all inferred TIs are categorized into one or more of the four major types of promoter architectures.Back to article page