Table 4 Gene set enrichment analysis
From: Identifying differentially methylated genes using mixed effect and generalized least square models
Gene sets | p-value | Genes in pathways |
|---|---|---|
Neuroactive ligand receptor interaction | 2.13 e-5 | EDNRB, GABBR1, GRIK2 |
Cytokine cytokine receptor interaction | 3.1 e-4 | KDR, EPOR, MPL, TGFB2, BMP2 |
Regulation of actin cytoskeleton | 9.21 e-4 | PIK3R2, PPP1CB, LIMK2, ARPC1B |
Focal adhesion | 4.81 e-3 | KDR, PIK3R2, PPP1CB, COL2A1, COL5A1 |
Natural killer cell mediated cytotoxicity | 4.97 e-3 | PIK3R2, NFATC3 |
Jak-STAT signaling pathway | 5.63 e-3 | EPOR, MPL, PIK3R2 |
Oxidative phosphorylation | 6.17 e-3 | ATP5A1, ATP12A |
Smooth muscle contraction | 6.53 e-3 | PLCB3, CALM1, PRKCE |
Purine metabolism | 8.35 e-3 | POLA1, ADA, IMPGH2 |
MAPK signaling pathway | 1.14 e-2 | MAP3K7, CACNA1C, CACNA1H, MKNK1, NTRK1, MAPKIP2, CACNG8, RASGRF2, TGFB2 |