Figure 8
From: Exploring complex miRNA-mRNA interactions with Bayesian networks by splitting-averaging strategy
A molecular network with functions in cancer, cellular movement, and gastrointestinal disease. 18 out of 34 mRNAs (colored in grey) in this network are identified by SA-BNs. Highlighted in graph, FN1 is a hub interacting with many other molecules involved in functions associated with EMT. SA-BNs suggest that miR-200b and miR-200c co-regulate FN1 for EMT. In addition, LOX, which was identified to interact with miR-200 family by SA-BNs, also involves in this network by interacting with many other molecules, including FN1.