Figure 9
From: Exploring complex miRNA-mRNA interactions with Bayesian networks by splitting-averaging strategy
A molecular network with function in cell morphology, skeletal and muscular system development and function, connective tissue development and function. 16 out of 35 mRNAs (colored in grey) in this network are identified by SA-BNs, including one of the validated targets of miR-200 family, ZEB1 (highlighted). In addition, JUN, regulated by miR-200b according to SA-BNs, interacts with many other molecules involved in apoptosis, proliferation, growth, transformation, cell death, morphology, cell cycle progression, survival, colony formation, and motility.