Exploring complex miRNA-mRNA interactions with Bayesian networks by splitting-averaging strategy

BMC Bioinformatics

Table 2 Validating targets against TarBase and miRecords

miRNA	Target gene	Predicated by SA-BNs for EMT	Validated Interaction for EMT	Support Database	Pubmed ID
miR-200a	ZEB2/SIP1	*	*	TarBase, miRecords	18376396
miR-200a	ZEB1/TCF8		*	TarBase, miRecords	18376396
miR-200b	RERE			miRecords	17923093
miR-200b	ZEB1/TCF8	*	*	TarBase, miRecords	18376396
miR-200b	ZEB2/SIP1	*	*	miRecords	18376396
miR-200c	ZEB1/TCF8	*	*	TarBase, miRecords	18483486
miR-200c	ZEB2/SIP1	*	*	TarBase	18381893
miR-141	CLOCK			TarBase, miRecords	15131085
miR-141	TGF-β		*	miRecords	18483486
miR-155	AGTR1/AT1R			TarBase, miRecords	16675453, 17668390, 7588946
miR-155	BACH-1			TarBase, miRecords	17881434
miR-155	LDOC1			TarBase, miRecords	17881434
miR-155	MATR3			TarBase, miRecords	17881434
miR-155	TM6SF1			TarBase, miRecords	17881434
miR-203	SOCS-3			miRecords	17622355
miR-203	P63			miRecords	18483491

16 target relationships consisting of 6 miRNAs and 12 mRNAs have experimental supports from TarBase and miRecords. Among them, 5 out of 7 identified miRNA-mRNA interactions by SA-BNs have been confirmed experimentally for EMT (denoted by *).

ISSN: 1471-2105