Figure 2

NPM1 gene signature from Verhaak et al. Verhaak et al. [57] published a NPM1 signature of 68 accession numbers that correspond to 40 genes. These genes were measured by 89 probe sets in the query dataset. A bar is plotted for each probe representing the value contributed by that probe set to the global test statistic. The expectation of these values under the null hypothesis of no correlation between NPM1 status and gene expression in the query dataset is indicated by the vertical black line. Overall, most genes reported by Verhaak et al. were also highly correlated with the NPM1 mutation status in our dataset. The colors indicate the direction of regulation. E.g., CD200 and BAALC were downregulated in NPM1-mutated samples, while most of the HOXA@ and HOXB@ genes showed increased expression in NPM1-mutated AML samples with a normal karyotype.