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Figure 3 | BMC Bioinformatics

Figure 3

From: Quantitative comparison of microarray experiments with published leukemia related gene expression signatures

Figure 3

t(11q23)/MLL gene signature from Ross et al. Gene-wise test statistics are shown for a subset of 85 probe sets allocated to genes as reported by Ross et al. [59] to be associated with translocation t(11q23)/MLL. The full plot with all 185 probe sets that could be mapped to the signature from Ross et al. (100 accession numbers) is provided online [Additional file 1: Supplemental Figure S1]. The high correlation of the expression pattern of the Ross et al. signature with the NPM1 status in the query dataset was mainly caused by the TALE genes (MEIS1 and PBX3) and by some HOXA@ family genes. This was characteristic for the t(11q23)/MLL signatures in our database and is consistent with results reported in [61].

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