Rank | unadjusted p-value | Term | Number of signatures | Number of articles |
---|
1 | < 0.001 | NPM1 mutated | 8 | 4 |
2 | 0.028 | t(11q23)/MLL | 9 | 6 |
3 | 0.071 |
CEBPA
| 7 | 5 |
4 | 0.087 | del(7q) | 1 | 1 |
5 | 0.113 |
FLT3
| 6 | 3 |
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- Taxonomy terms were assessed based on the ranking of the gene signatures associated with those terms. In case of the example dataset examining NPM1-mutations, the 8 NPM1 signatures that were extracted from 4 different articles significantly occupied low ranks. The low p-value of translocation t(11q23)/MLL indicates a putative relation between this translocation and the studied NPM1-mutation. The full ranking of all taxonomy terms is provided in the supplement [Additional file 1: Supplemental Table S5]. The ranking remained reasonably stable when (i) half of the arrays were excluded from the analysis [Additional file 1: Supplemental Figure S2] and also when (ii) half of the gene signatures were excluded from the analysis [Additional file 1: Supplemental Figure S3].