Skip to main content

Table 3 Ranking of taxonomy terms.

From: Quantitative comparison of microarray experiments with published leukemia related gene expression signatures

Rank

unadjusted p-value

Term

Number of signatures

Number of articles

1

< 0.001

NPM1 mutated

8

4

2

0.028

t(11q23)/MLL

9

6

3

0.071

CEBPA

7

5

4

0.087

del(7q)

1

1

5

0.113

FLT3

6

3

â‹®

â‹®

â‹®

â‹®

â‹®

  1. Taxonomy terms were assessed based on the ranking of the gene signatures associated with those terms. In case of the example dataset examining NPM1-mutations, the 8 NPM1 signatures that were extracted from 4 different articles significantly occupied low ranks. The low p-value of translocation t(11q23)/MLL indicates a putative relation between this translocation and the studied NPM1-mutation. The full ranking of all taxonomy terms is provided in the supplement [Additional file 1: Supplemental Table S5]. The ranking remained reasonably stable when (i) half of the arrays were excluded from the analysis [Additional file 1: Supplemental Figure S2] and also when (ii) half of the gene signatures were excluded from the analysis [Additional file 1: Supplemental Figure S3].