Figure 1
From: Using mechanistic Bayesian networks to identify downstream targets of the Sonic Hedgehog pathway
BN and MBN modeling of Shh pathway: (a) A sequential BN model of the pathway that omits protein activity, (b) a parallel BN model of the pathway, and (c) an MBN model of the pathway. The ovals Shh, Ptch1 and Smo represent mRNA measurements, while the ovals, ShhP, Ptch1P and SmoP, represent proteins. The oval GeneX indicates a candidate downstream expression target of the pathway. Dotted ovals represent entities that are known in the mechanism but are not observed, while unbroken ovals represent experimentally observed variables. Arrows between nodes represent a directional interaction but do not specify the functional form.