Performance of Correlation and CRE Prediction Methods across microarray data: Regulated genes only. The overall pattern for the PPV (A), Sensitivity (B) and F-Measure (C), Specificity (D), and NPV (E) for the analysis of regulated genes using correlation and/or CRE detection prediction methods for determining TF targets. As shown here the PPV shows a generally consistent pattern across all datasets, while the sensitivity and F measure are shown to be higher for the Spearman, ≥ 1 CRE and Spearman + ≥ 1 CRE prediction methods (A-C). Also shown is the consistent pattern for specificity and NPV (D and E) across all prediction methods except the ≥ 1 CRE which shows a high degree of variability. PPV (positive predictive value), NPV (negative predictive value), CRE over.: CRE Over-representation, ≥1 CRE: detection of 1 or more CREs.