Skip to main content

Table 1 Results for protein disorder predictors that participated in CASP8 on 117 targets.

From: PreDisorder: ab initio sequence-based prediction of protein disordered regions

Disorder Predictor ROC Score Weighed Score Total Res. Pos. Sens. Pos. Spec. Neg. Sens. Neg. Spec. Sens. Prod. F-meas.
MULTICOM 0.879 6.89 25148 0.532 0.619 0.973 0.962 0.518 0.572
DISOclust 0.862 7.822 24021 0.753 0.248 0.813 0.976 0.612 0.373
fais-server 0.861 6.613 24021 0.522 0.533 0.963 0.961 0.503 0.528
MULTICOM-CMFR* 0.859 8.06 25431 0.724 0.299 0.859 0.974 0.622 0.423
3Dpro* 0.855 4.826 23934 0.378 0.727 0.988 0.949 0.373 0.497
GS-MetaServer 0.852 5.356 24976 0.41 0.711 0.986 0.953 0.404 0.52
mariner1* 0.846 7.469 23148 0.622 0.396 0.923 0.968 0.574 0.484
Distill-Punch* 0.846 0.798 23311 0.067 0.75 0.998 0.93 0.067 0.123
Metaprdos 0.842 6.431 22363 0.505 0.539 0.966 0.961 0.488 0.522
Distill-Punch* 0.839 0.823 23730 0.063 0.881 0.999 0.93 0.063 0.118
CBRC_POODLE* 0.839 6.259 24021 0.522 0.403 0.937 0.96 0.489 0.455
GeneSilicoMeta 0.839 6.338 24976 0.489 0.627 0.976 0.959 0.478 0.55
DISOPRED* 0.831 6.497 24021 0.522 0.485 0.955 0.961 0.498 0.503
Biomine* 0.825 6.394 23472 0.517 0.47 0.952 0.96 0.492 0.493
OnD-CRF* 0.82 5.214 24021 0.47 0.31 0.914 0.955 0.429 0.373
Spritz* 0.791 5.431 24021 0.434 0.514 0.966 0.954 0.42 0.471
GSMetaDisorder 0.772 6.31 24504 0.579 0.289 0.88 0.961 0.51 0.386
Distill* 0.758 5.637 24021 0.671 0.173 0.738 0.965 0.495 0.276
LEE-SERVER* 0.741 3.595 21955 0.31 0.449 0.968 0.943 0.3 0.367
  1. Results of our evaluation of all the protein disorder predictors ranked by ROC Score (AUC). Total Res. represents the total number of residues predicted. Pos. Spec. and Neg. Spec. are the positive and negative specificities. Pos. Sens. and Neg. Sens. are the positive and negative sensitivities. F-meas. is the F-Measure of the positive sensitivity and positive specificity and Sens. Prod. is the product of the positive sensitivity and negative sensitivity. * denotes ab initio methods. MULTICOM-CMFR is the predictor name of PreDisorder in CASP8.