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Table 6 IRIS results for the MYC subnetwork including 55 genes directly connected to MYC.

From: IRIS: a method for reverse engineering of regulatory relations in gene networks

Gene

IRIS Inferred Regulation

MYC-DB Regulation

HSPC111

Upregulation

Upregulation

PPAT

Upregulation

Upregulation

POLD2

Upregulation

Upregulation

NOL5A

Upregulation

Upregulation

ZRP1

Downregulation

Upregulation

NME1

Undefined

Upregulation

EBNA1BP2

Upregulation

Upregulation

APEX1

Upregulation

Upregulation

NDUFB5

Undefined

Not Specified

PSPH

Upregulation

Upregulation

EEF1E1

Upregulation

Not Specified

CTPS

Upregulation

Upregulation

C1QBP

Upregulation

Upregulation

SRM

Undefined

Upregulation

CCT3

Upregulation

Upregulation

NOLC1

Upregulation

Upregulation

JTV1

Upregulation

Upregulation

TRAP1

Upregulation

Not Specified

BOP1

Undefined

Upregulation

IARS

Upregulation

Upregulation

EIF3S9

Upregulation

Upregulation

PAICS

Upregulation

Not Specified

RRS1

Upregulation

Upregulation

RCL

Undefined

Upregulation

POLR1C

Upregulation

Not Present

DKFZP564M182

Downregulation

Not Present

HPRT1

Upregulation

Not Present

C4orf9

Upregulation

Not Present

MRPL9

Upregulation

Not Present

LOC283537

Downregulation

Not Present

STAT3

Downregulation

Not Present

TUFM

Undefined

Not Present

SUPV3L1

Upregulation

Not Present

MRPL3

Upregulation

Not Present

LIMK2

Upregulation

Not Present

ATP6VOD1

Downregulation

Not Present

MX1

Upregulation

Not Present

TOMM40

Upregulation

Not Present

CYC1

Upregulation

Not Present

NOLA2

Upregulation

Not Present

MRPL12

Upregulation

Not Present

TIP-1

Undefined

Not Present

BYSL

Upregulation

Not Present

PFAS

Upregulation

Not Present

ZT86

Undefined

Not Present

TRA@

Undefined

Not Present

PRMT3

Upregulation

Not Present

MGC27165

Undefined

Not Present

ATIC

Upregulation

Not Present

HSD17B8

Upregulation

Not Present

SSRP1

Undefined

Not Present

TEGT

Downregulation

Not Present

TCP1

Upregulation

Not Present

Cdna_flj30991

Undefined

Not Present

IDH3A

Upregulation

Not Present

  1. Note: Not Specified indicates a gene for which an entry exists in MYC-DB but for which no information on regulation is available; Not Present indicates a gene for which no entry in MYC-DB exists; Undefined indicates a situation for which IRIS cannot distinguish between up- and down-regulation.