Gold Standard Topology and Simulated Data. (a) True network of the DREAM 2 challenge #3 five gene time series data, showing the bio-engineered interactions between the five genes artificially inserted into yeast. (b) Time course of simulation with model in arbitrary time and concentration units, for the simulated five gene model. Different numbers of equidistant time points from this data were used for network reconstruction in the simulation study. The time courses of gene 2 and gene 3 are almost the same.