True positive rates across concentration. True positive rates across concentration using a p < 0.05 threshold. (A) HGU133A Latin Square data. (B) Local variance model "spike-in" simulated data with high variance (n = 3). Differential expression tests: FC: Fold Change, limma: limma moderated t-statistic, BRB: BRB t-statistic, CyberT: CyberT t-statistic, LPE: LPE z-statistic, t-stat: t-statistic. The limma and BRB t-statistic produce comparable results and consequently limma's orange line often conceals BRB's green line.