Predicting functional upstream open reading frames in Saccharomyces cerevisiae

BMC Bioinformatics

Table 5 Comparison between predictions made by our hypotheses (Table 4) and by [32] for the seven genes that they wet-experimentally tested.

Gene Name	Systematic Name	uORF's Position	uORF's Length	Predicted as functional in
				Z&D	This study
RPC11	YDR045C	-60	4	Yes	Yes
TPK1	YJL164C	-42	5	Yes	Yes
FOL1	YNL256W	-65	4	Yes	Yes
WSC3	YOL105C	-50	7	Yes	a
MKK1	YOR231W	-71	10	Yes	No
ECM7	YLR443W	-15	5	No^b	No
IMD4	YML056C	-99	14	No^b	No

^a5' UTR length was predicted to be well over 1000 bases and thus this gene is not included in this study.
^bZhang and Dietrich found these uORFs have little effect on translation; we consider them as non-functional.

ISSN: 1471-2105