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Table 4 Comparison of methods for assigning significance.

From: A general modular framework for gene set enrichment analysis

 

parametric

resampling

permutation

restandardization

set 1

0.82

0.67

0.59

0.66

set 2

1.00

0.92

1.00

0.92

set 3

0.03

0.01

0.06

0.01

set 4

0.60

0.44

0.51

0.43

set 5

0.85

0.41

0.90

0.41

set 6

0.96

0.85

0.83

0.84

set 7

1.00

1.00

1.00

1.00

set 8

0.90

0.70

0.79

0.68

set 9

0.99

0.90

1.00

0.87

  1. The values indicated are the proportion of p-values ≤ 0.05 using the gene set statistic mean of the individual squared moderated t-statistics.