Figure 4

MSA showing the outcome of in silico recapitulation experiments for cytochrome P450 2B4. Different combinations of modules were used to generate models in a recapitulation experiment. The first column lists the module combination, the last column the number and fraction of correctly determined residues belonging to ACT_CENT. The last line gives the native sequence as deduced from pdb-entry 1po5. Recapitulated residues are indicated by a gray background. Abbreviations for modules are: ST (stability), LB (ligand binding), KP (knowledge-based potential) and PK (pK_a values).