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Table 3 Basic differences between housekeeping and tissue specific genes.

From: ContDist: a tool for the analysis of quantitative gene and promoter properties

 

housekeeping

tissue specific

   

Feature

Mean

median

mean

median

ratio

p-valueKS

p-valueRand

CG density in R3

0.086

0.088

0.064

0.060

0.416

7.16E-80

0.0001

G+C in R2

65.6

66.7

61.8

62.7

0.085

1.83E-27

0.0001

G+C in R3

64.6

65.6

60.9

62.3

0.086

1.06E-25

0.0001

G+C in R4

58.7

58.8

56.3

56.9

0.061

1.66E-17

0.0001

G+C in R6

51.7

51.3

50.6

50.4

0.033

1.31E-17

0.0001

G+C in Intron

46.6

45.6

47.1

45.8

-0.016

5.22E-06

0.0514

Ka/Ks (hsa/mmu)

0.100

0.074

0.151

0.125

- 0.594

8.25E-35

0.0001

Subst. per aa

(hsa/mmu)

0.107

0.082

0.171

0.147

- 0.675

2.76E-47

0.0001

PPI

7.9

3.0

4.8

2.0

0.728

7.28E-10

0.0004

mean Expr.

2264.1

1137.7

933.4

287.3

1.278

0.00E+00

0.0001

peak Expr.

9716.4

3660.3

2229.0

357.8

2.124

0.00E+00

0.0001

CDS length

1532.6

1170.0

1703.0

1335.0

- 0.152

2.34E-10

0.0001

mRNA length

2900.4

2439.5

2964.7

2427.0

-0.032

9.48E-01

0.2685

  1. The tool permits to confirm quickly some known aspects like the difference in expression levels, association to CpG islands and higher conservation of HK genes. The tool also detects that HK genes products have on average more interaction partners, a finding which to our knowledge has not been reported so far.