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Table 10 Dispositions of the conventional DC subtypes.

From: An improved ontological representation of dendritic cells as a paradigm for all cell types

 

disposition to circulate in the blood

disposition to cross-present antigen to CD8+ T cells

disposition to migrate to the lymph node

disposition to secrete anti- inflammatory cytokines

disposition to secrete inflammatory cytokines

disposition to secrete type 1 interferon

CD8α-CD11b- DC

      

   immature

      

   CD8α-CD11b-DC

      

   mature

   

+

  

   CD8α-CD11b-DC

      

CD8α- CD11b+ DC

   

+

  

   immature

   

+

  

   CD8α- CD11b+DC

      

   mature

   

+

  

   CD8α- CD11b+DC

      

CD8α + CD11b-DC

 

+

  

+

 

   immature

 

+

  

+

 

   CD8α + CD11b-DC

      

   mature

 

+

  

+

 

   CD8α + CD11b-DC

      

interstitial DC

      

   immature

  

+

   

   interstitial DC

      

   mature

      

   interstitial DC

      

Langerhans cell

      

   CD1a+

      

   Langerhans cell

      

immature

  

+

   

CD1a+

      

Langerhans cell

      

mature

      

CD1a+

      

Langerhans cell

      

   CD8αlow

  

+

 

+

 

   Langerhans cell

      

immature

  

+

 

+

 

CD8αlow

      

Langerhans cell

      

mature

  

+

 

+

 

CD8αlow

      

Langerhans cell

      

dermal DC

      

   immature

  

+

   

   dermal DC

      

   mature dermal DC

      
  1. + indicates the cell type referred to by the row label is related to the disposition referred to by the column heading using the has_disposition relation.