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Table 2 Surface protein combinations defining the subtypes of conventional dendritic cell.

From: An improved ontological representation of dendritic cells as a paradigm for all cell types

  205 11b 4 1a 206 209 36 14 207 324 80 83 86 MHC
II
CD8α-CD11b- DC + - - -            
   immature + - - -         L   L L
   CD8α-CD11b- DC                
   mature + - - -         H + H H
   CD8α-CD11b- DC                
CD8α- CD11b+ DC - + + -            
   immature - + + -         L   L L
   CD8α- CD11b+ DC                
   mature - + + -         H + H H
   CD8α- CD11b+ DC                
CD8α + CD11b- DC + - - +            
   immature + - - +         L   L L
   CD8α + CD11b- DC                
   mature + - - +         H + H H
   CD8α + CD11b- DC                
interstitial DC   +    + + +         
   immature   +    + + +      L   L L
   interstitial DC                
   mature   +    + + +      H + H H
   interstitial DC                
Langerhans cell           +      
   CD1a+ Langerhans cell      +      + +     
immature CD1a+      +      + + L   L L
Langerhans cell                
mature CD1a+      +      + + H + H H
Langerhans cell                
   CD8αlow Langerhans cell H    L       +      
immature CD8αlow H    L       +   L   L L
Langerhans cell                
mature CD8αlow H    L       +   H + H H
Langerhans cell                
dermal DC + +   -            
   immature dermal DC + +   -         L   L L
   mature dermal DC + +   -         H + H H
  1. Column headings show protein or protein complex names. Numbers correspond to CD antigens (e.g. CD205 is referred to as 205 in the table). Row labels show the terms for subtypes of conventional dendritic cell defined in DC-CL. Row labels not indented correspond to direct subtypes of conventional dendritic cell; indented row labels correspond to direct subtypes of the types referred to by the nearest, above row with less indent. + indicates that the has_plasma_membrane_part relation is use to join the cell type term to the protein or protein complex term; – indicates that the lacks_plasma_membrane_part relation is used; L indicates that the has_low_plasma_membrane_amount relation is used; and H indicates that the has_high_plasma_membrane_amount relation is used.