TY - JOUR AU - Wilczynski, Bartek AU - Dojer, Norbert AU - Patelak, Mateusz AU - Tiuryn, Jerzy PY - 2009 DA - 2009/03/10 TI - Finding evolutionarily conserved cis-regulatory modules with a universal set of motifs JO - BMC Bioinformatics SP - 82 VL - 10 IS - 1 AB - Finding functional regulatory elements in DNA sequences is a very important problem in computational biology and providing a reliable algorithm for this task would be a major step towards understanding regulatory mechanisms on genome-wide scale. Major obstacles in this respect are that the fact that the amount of non-coding DNA is vast, and that the methods for predicting functional transcription factor binding sites tend to produce results with a high percentage of false positives. This makes the problem of finding regions significantly enriched in binding sites difficult. SN - 1471-2105 UR - https://doi.org/10.1186/1471-2105-10-82 DO - 10.1186/1471-2105-10-82 ID - Wilczynski2009 ER -