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Table 3 38 oncogene domains present in virus dataset (367,752 proteins).

From: Analyses of domains and domain fusions in human proto-oncogenes

Num

Pfam accession id

Pfam entry id

Frequency of occurrence in virus proteome

Description of domain family

1

PF00271

Helicase_C

1455

Helicase conserved C-terminal domain

2

PF00023

Ank

459

Ankyrin repeat

3

PF00270

DEAD

296

DEAD/DEAH box helicase

4

PF00097

zf-C3HC4

168

Zinc finger, C3HC4 type (RING finger)

5

PF00069

Pkinase

162

Protein kinase domain

6

PF00001

7tm_1

115

7 transmembrane receptor (rhodopsin family)

7

PF00047

ig

111

Immunoglobulin domain

8

PF07686

V-set

110

Immunoglobulin V-set domain

9

PF00048

IL8

87

Small cytokines (intecrine/chemokine), interleukin-8 like

10

PF00170

bZIP_1

50

bZIP transcription factor

11

PF01403

Sema

47

Sema domain

12

PF00167

FGF

33

Fibroblast growth factor

13

PF07714

Pkinase_Tyr

30

Protein tyrosine kinase

14

PF00096

zf-C2H2

22

Zinc finger, C2H2 type

15

PF00017

SH2

21

SH2 domain

16

PF00560

LRR_1

17

Leucine Rich Repeat

17

PF00018/PF07653

SH3

16

SH3 domain

18

PF00605

IRF

16

Interferon regulatory factor transcription factor

19

PF00041

fn3

15

Fibronectin type III domain

20

PF00341

PDGF

14

Platelet-derived growth factor

21

PF00452

Bcl-2

12

Apoptosis regulator proteins, Bcl-2 family

22

PF00134

Cyclin_N

11

Cyclin, N-terminal domain

23

PF01056

Myc_N

11

Myc amino-terminal region

24

PF00010

HLH

10

Helix-loop-helix DNA-binding domain

25

PF07679

I-set

8

Immunoglobulin I-set domain

26

PF02344

Myc-LZ

6

Myc leucine zipper domain

27

PF00076

RRM_1

5

RNA recognition motif

28

PF01437

PSI

5

Plexin repeat

29

PF02201

SWIB

5

SWIB/MDM2 domain

30

PF00104

Hormone_recep

3

Ligand-binding domain of nuclear hormone receptor

31

PF00105

zf-C4

3

Zinc finger, C4 type

32

PF07716

bZIP_2

2

Basic region leucine zipper

33

PF07988

Wos2

2

Mitotic protein Wos2

34

PF00071

Ras

1

Ras family

35

PF00595

PDZ

1

PDZ domain

36

PF00611

FCH

1

Fes/CIP4 homology domain

37

PF02757

YLP

1

YLP motif

38

PF04692

PDGF_N

1

Platelet-derived growth factor, N terminal