Table 4 24 oncogenes whose domain fusion events arose in prokaryotes.

MOS

{Pkinase}

A_B

P

SPINK1

{Kazal_1}

B

/

NRAS

{Ras}

A_B

P

HRAS

{Ras}

A_B

P

KRAS

{Ras}

A_B

P

GLI2

{zf-C2H2}

A_B

P

GLI3

{zf-C2H2}

A_B

P

MYBL2

{Myb_DNA-binding}

B

/

RALA

{Ras}

A_B

P

RALB

{Ras}

A_B

P

PIM1

{Pkinase}

A_B

P

CDK4

{Pkinase}

A_B

P

FOSL1

{bZIP_1}

A

P

TAL1

{HLH}

B

P

BCL3

{Ank}

A_B

P

DDX6

{DEAD, Helicase_C}

A_B

P

NKTR

{Pro_isomerase}

A_B

/

BMI1

{zf-C3HC4}

B

P

TGFBR2

{Pkinase}

A_B

P

MPL

{fn3}

A_B

P

MSH2

{MutS_V, MutS_I, MutS_II, MutS_IV, MutS_III}

A_B

/

RAB8A

{Ras}

A_B

P

MAX

{HLH}

B

P

EVI1

{zf-C2H2}

A_B

P