Array | Flagging | # probes | Method | Sens. | Spec. | PPV | NPV |
|---|
S. aureus
| Weak | 4515 | BCSP | 0.968 | 0.938 | 0.987 | 0.861 |
| | | | Mix.mod. | 0.945 | 0.901 | 0.979 | 0.776 |
| | | | p-value | 4.1·10-7 | 7.4·10-4 | 1.7·10-4 | 2.5·10-7 |
| | Hard | 3539 | BCSP | 0.977 | 0.864 | 0.989 | 0.754 |
| | | | Mix.mod. | 0.960 | 0.825 | 0.985 | 0.607 |
| | | | p-value | 3.2·10-8 | 0.02 | 0.003 | 3.7·10-8 |
E. faecalis
| Weak | 3228 | BCSP | 0.989 | 0.953 | 0.983 | 0.560 |
| | | | Mix.mod. | 0.946 | 0.890 | 0.989 | 0.458 |
| | Hard | 3145 | BCSP | 0.992 | 0.0 | 0.869 | 0.0 |
| | | | Mix.mod. | 0.955 | 0.474 | 0.990 | 0.409 |
- Classification of probes into Present/Absent was done after both weak and hard flagging, see text for details, and using both our bias-corrected S-signal prediction method (BCSP) and the gaussian mixture model method. The number of probes indicate the median number of ordinary probes in a data set after flagging. All the results shown (Sens., Spec., PPV and NPV) are averages over the 28 S. aureus or 4 E. faecalis data sets. The p-values listed for the S. aureus results are the outcome of a Wilcoxon signrank test of wether the BCSP-method is a significant improvement of the mixture model method. A smaller p-value indicate a significant improvement. For the E. faecalis results all p-values were large (> 0.10) and they are not listed.
