HIV-1 interacting drug target genes. This network shows 237 human genes that encode products that are HIV-1 interacting and FDA-approved drug targets. HIV-1 elements are labelled. Human genes are colored according to the number of distinct HIV-1 elements with which they share an interaction (darker = more). The layout of this network was achieved by manually positioning the HIV-1 nodes, locking them in position and allowing the JNets spring layout to reposition the remaining human gene nodes. As a result, human gene nodes with multiple interactors are drawn to the centre of the network. From this visualization it is clear that many HIDTs interact with multiple HIV-1 elements and that certain HIV-1 elements are responsible for many more HIV-HIDT interactions than others. Such observations can be investigated in greater detail using JNets. For example, 114 from 237 of these human genes interact with more than one HIV-1 element. This is significantly more than would be expected at random (p < 0.001).