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Table 2 HIV-1 interacting drug target genes by drug category.

From: JNets: Exploring networks by integrating annotation

Level-2 ATC description

Target genes

HIV-1 interacting

Corrected p

Immunosuppressive agents

36 (3%)

29 (12%)

1.87 × 10-13

Antineoplastic agents

100 (8%)

47 (20%)

7.87 × 10-9

Anti-inflammitory and antirheumatic products

27 (2%)

18 (8%)

3.03 × 10-6

Stomatological preparations

30 (3%)

19 (8%)

3.35 × 10-6

Lipid modifying agents

46 (4%)

23 (10%)

4.62 × 10-5

Antithrombotic agents

65 (5%)

29 (12%)

4.08 × 10-5

  1. The proportion of drug target genes that encode HIV-1 interacting products, compared to the total number of drug target genes, grouped by the level-2 ATC categories of targeting drugs are shown. The statistical significance of the difference in expected and actual figures, indicated by p-values, were calculated in JNets, using two-tailed Fisher's Exact tests, corrected for multiple testing using the Benjamini and Hochberg method [15]. We have only shown those categories where p < 0.001; all showed over-representation.