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Table 2 HIV-1 interacting drug target genes by drug category.

From: JNets: Exploring networks by integrating annotation

Level-2 ATC description Target genes HIV-1 interacting Corrected p
Immunosuppressive agents 36 (3%) 29 (12%) 1.87 × 10-13
Antineoplastic agents 100 (8%) 47 (20%) 7.87 × 10-9
Anti-inflammitory and antirheumatic products 27 (2%) 18 (8%) 3.03 × 10-6
Stomatological preparations 30 (3%) 19 (8%) 3.35 × 10-6
Lipid modifying agents 46 (4%) 23 (10%) 4.62 × 10-5
Antithrombotic agents 65 (5%) 29 (12%) 4.08 × 10-5
  1. The proportion of drug target genes that encode HIV-1 interacting products, compared to the total number of drug target genes, grouped by the level-2 ATC categories of targeting drugs are shown. The statistical significance of the difference in expected and actual figures, indicated by p-values, were calculated in JNets, using two-tailed Fisher's Exact tests, corrected for multiple testing using the Benjamini and Hochberg method [15]. We have only shown those categories where p < 0.001; all showed over-representation.