TY - JOUR AU - Kolářik, Corinna AU - Klinger, Roman AU - Hofmann-Apitius, Martin PY - 2009 DA - 2009/01/30 TI - Identification of histone modifications in biomedical text for supporting epigenomic research JO - BMC Bioinformatics SP - S28 VL - 10 IS - 1 AB - Posttranslational modifications of histones influence the structure of chromatine and in such a way take part in the regulation of gene expression. Certain histone modification patterns, distributed over the genome, are connected to cell as well as tissue differentiation and to the adaption of organisms to their environment. Abnormal changes instead influence the development of disease states like cancer. The regulation mechanisms for modifying histones and its functionalities are the subject of epigenomics investigation and are still not completely understood. Text provides a rich resource of knowledge on epigenomics and modifications of histones in particular. It contains information about experimental studies, the conditions used, and results. To our knowledge, no approach has been published so far for identifying histone modifications in text. SN - 1471-2105 UR - https://doi.org/10.1186/1471-2105-10-S1-S28 DO - 10.1186/1471-2105-10-S1-S28 ID - Kolářik2009 ER -