Figure 5

The increased peak concentration (A) and the signal duration (B) of nuclear phosphorylated STAT dimers in the model with JAK2V617F proteins. The gray and black bars represent the wild type and JAK2V617F mutant model, and the numbers on the black bars denote the ratio of the concentration of [STAT*Dn] in the model with JAK2V617F to the model with the wild type JAK2 protein. We assumed [STAT*Dn] was 1 nM for the model with wild type JAK2 without ligands and the continuance duration was 0.1 hour to calculate fold changes in the model with the mutant JAK2V617F.