Figure 2
From: Copy-number-variation and copy-number-alteration region detection by cumulative plots
Cumulative plot of log-ratio and homozygosity sequence. Cumulative plot and detrended cumulative plot for both the log-ratio sequence and the homozygosity indicator sequence (for the chromosome 13 data shown in Figure 1). Top: cumulative plots for log-ratio sequence. Bottom: cumulative plot for homozygosity sequence (1 for homozygote, -1 for heterozygote). Left: original cumulative plots. Right: detrended cumulative plots. The linear trend obtained from the normal sample is used to detrend both the normal and the cancer sample. Black for the normal cell and blue for the cancer cell. The 9 MB hemizygous deletion and the neighboring 1 Mb homozygous deletion region are marked by red lines.