Simplified architecture of argumentation system. A human expert created Argumentation Schemes that modelled their knowledge of how to interpret the gene expression results in EMAGE and GXD (two in-situ gene expression databases for the Developmental Mouse). These schemes were converted into rules, and used by the ASPIC Argumentation engine to create arguments. The other ingredient for arguments, is experimental information from EMAGE and GXD – this was pulled when the user specified a gene-structure pair through the User Interface. Arguments were created in response to a query – is gene expressed in structure? – and returned to the user.