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Table 5 TREC Genomics 2006 questions and keywords

From: GoWeb: a semantic search engine for the life science web

160 What is the role of PrnP in mad cow disease? PrnP
161 What is the role of IDE in Alzheimer's disease? IDE Alzheimer
162 What is the role of MMS2 in cancer? MMS2
163 What is the role of APC (adenomatous polyposis coli) in colon cancer? APC adenomatous polyposis coli
164 What is the role of Nurr-77 in Parkinson's disease? Nurr-77
165 How do Cathepsin D (CTSD) and apolipoprotein E (ApoE) interactions contribute to Alzheimer's disease? "Cathepsin D" "apolipoprotein E"
166 What is the role of Transforming growth factor-beta1 (TGF-beta1) in cerebral amyloid angiopathy (CAA)? TGF-beta1 cerebral amyloid angiopathy
167 How does nucleoside diphosphate kinase (NM23) contribute to tumor progression? NM23 tumor progression
168 How does BARD1 regulate BRCA1 activity? BARD1 BRCA1
169 How does APC (adenomatous polyposis coli) protein affect actin assembly? adenomatous polyposis coli actin assembly
170 How does COP2 contribute to CFTR export from the endoplasmic reticulum? COP2 CFTR
171 How does Nurr-77 delete T cells before they migrate to the spleen or lymph nodes and how does this impact autoimmunity? Nurr-77 T cell
172 How does p53 affect apoptosis? p53 apoptosis
173 How do alpha7 nicotinic receptor subunits affect ethanol metabolism? alpha7 nicotinic receptor ethanol
174 How does BRCA1 ubiquitinating activity contribute to cancer? BRCA1 ubiquitinating
175 How does L2 interact with L1 to form HPV11 viral capsids? L1 L2 HPV11
176 How does Sec61-mediated CFTR degradation contribute to cystic fibrosis? Sec61 CFTR
177 How do Bop-Pes interactions affect cell growth? Bop Pes cell growth
178 How do interactions between insulin-like GFs and the insulin receptor affect skin biology? insulin-like GF insulin receptor
179 How do interactions between HNF4 and COUP-TF1 suppress liver function? HNF4 COUP-TF1
180 How do Ret-GDNF interactions affect liver development? Ret GDNF liver
181 How do mutations in the Huntingtin gene affect Huntington's disease? Huntingtin gene
182 How do mutations in Sonic Hedgehog genes affect developmental disorders? Sonic Hedgehog gene
183 How do mutations in the NM23 gene affect tracheal development? NM23 tracheal development
184 How do mutations in the Pes gene affect cell growth? Pes gene cell growth
185 How do mutations in the hypocretin receptor 2 gene affect narcolepsy? hypocretin receptor 2 narcolepsy
186 How do mutations in the Presenilin-1 gene affect Alzheimer's disease? Presenilin-1 Alzheimer
187 How do mutations in familial hemiplegic migraine type 1 (FHM1) gene affect calcium ion in ux in hippocampal neurons? FHM1 calcium neuron