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Table 5 TREC Genomics 2006 questions and keywords

From: GoWeb: a semantic search engine for the life science web

160

What is the role of PrnP in mad cow disease?

PrnP

161

What is the role of IDE in Alzheimer's disease?

IDE Alzheimer

162

What is the role of MMS2 in cancer?

MMS2

163

What is the role of APC (adenomatous polyposis coli) in colon cancer?

APC adenomatous polyposis coli

164

What is the role of Nurr-77 in Parkinson's disease?

Nurr-77

165

How do Cathepsin D (CTSD) and apolipoprotein E (ApoE) interactions contribute to Alzheimer's disease?

"Cathepsin D" "apolipoprotein E"

166

What is the role of Transforming growth factor-beta1 (TGF-beta1) in cerebral amyloid angiopathy (CAA)?

TGF-beta1 cerebral amyloid angiopathy

167

How does nucleoside diphosphate kinase (NM23) contribute to tumor progression?

NM23 tumor progression

168

How does BARD1 regulate BRCA1 activity?

BARD1 BRCA1

169

How does APC (adenomatous polyposis coli) protein affect actin assembly?

adenomatous polyposis coli actin assembly

170

How does COP2 contribute to CFTR export from the endoplasmic reticulum?

COP2 CFTR

171

How does Nurr-77 delete T cells before they migrate to the spleen or lymph nodes and how does this impact autoimmunity?

Nurr-77 T cell

172

How does p53 affect apoptosis?

p53 apoptosis

173

How do alpha7 nicotinic receptor subunits affect ethanol metabolism?

alpha7 nicotinic receptor ethanol

174

How does BRCA1 ubiquitinating activity contribute to cancer?

BRCA1 ubiquitinating

175

How does L2 interact with L1 to form HPV11 viral capsids?

L1 L2 HPV11

176

How does Sec61-mediated CFTR degradation contribute to cystic fibrosis?

Sec61 CFTR

177

How do Bop-Pes interactions affect cell growth?

Bop Pes cell growth

178

How do interactions between insulin-like GFs and the insulin receptor affect skin biology?

insulin-like GF insulin receptor

179

How do interactions between HNF4 and COUP-TF1 suppress liver function?

HNF4 COUP-TF1

180

How do Ret-GDNF interactions affect liver development?

Ret GDNF liver

181

How do mutations in the Huntingtin gene affect Huntington's disease?

Huntingtin gene

182

How do mutations in Sonic Hedgehog genes affect developmental disorders?

Sonic Hedgehog gene

183

How do mutations in the NM23 gene affect tracheal development?

NM23 tracheal development

184

How do mutations in the Pes gene affect cell growth?

Pes gene cell growth

185

How do mutations in the hypocretin receptor 2 gene affect narcolepsy?

hypocretin receptor 2 narcolepsy

186

How do mutations in the Presenilin-1 gene affect Alzheimer's disease?

Presenilin-1 Alzheimer

187

How do mutations in familial hemiplegic migraine type 1 (FHM1) gene affect calcium ion in ux in hippocampal neurons?

FHM1 calcium neuron