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Table 6 Answers for TREC Genomics 2006 questions 160 to 164

From: GoWeb: a semantic search engine for the life science web

Concept original Pos Evidence
160 Encephalopathy, Bovine Spongiform 378: Transmissible Spongiform Encephalopathy (BSE) Bovine spongiform encepalopathy is a transmissible, ... Mutations in the PRNP gene cause prion disease. ... http://www.answers.com/topic/spongiform-encephalopathy
161 1: Insulin-Degrading Enzyme as a Downstream Target of Insulin Receptor ... effect relationship between insulin signaling and IDE upregulation. ... P85) was correlated with reduced IDE in Alzheimer's disease (AD) brains and in ... http://alzheimer.neurology.ucla.edu/pubs/IDEzhao.pdf
  2: Insulin degrading enzyme – Wikipedia, the free encyclopedia 1 IDE and Alzheimer's Disease. 2 IDE Structure and Function. 3 References. 4 External links ... between IDE, Aβ degradation, and Alzheimer's disease. ... http://en.wikipedia.org/wiki/Insulin_degrading_enzyme
162 DNA Damage 41: ... concerted action of RAD5 with UBC13 and MMS2 in DNA damage repair is given by ... Finally, it is shown that MMS2, like UBC13 and many other repair genes, is ... http://db.yeastgenome.org/cgi-bin/reference/reference.pl?dbid=S000061270
163 1: The official name of this gene is "adenomatous polyposis coli." APC is the gene's official symbol. ... adenomatous polyposis – caused by mutations in the APC ... http://ghr.nlm.nih.gov/gene=apc
164 Parkinson Disease 40: The aetiology of idiopathic Parkinson's disease Nurr 1 was first recognised as a transcription factor that was primarily ... Its close structural relation to Nur 77 led to its identification in stimulated ... http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1187126
  132: Concise Review: Therapeutic Strategies for Parkinson Disease Based on ... nuclear related receptor 1 (Nurr-1), thereby withdrawing the cells of the cell ... in the SVZ and the substantia nigra of the healthy adult rat brain [77, 98] ... http://stemcells.alphamedpress.org/cgi/content/full/25/2/263
  221: Parkinson's disease: piecing together a genetic jigsaw – Dekker et al ... study decreased rapidly with later onset: 77% of patients with onset of disease ... agenesis of mesencephalic dopaminergic neurons in Nurr-1 deficient mice. ... http://brain.oxfordjournals.org/cgi/content/full/126/8/1722