TY - JOUR AU - Garcia-Reyero, Natàlia AU - Adelman, Ira R. AU - Martinović, Dalma AU - Liu, Li AU - Denslow, Nancy D. PY - 2009 DA - 2009/10/08 TI - Site-specific impacts on gene expression and behavior in fathead minnows (Pimephales promelas) exposed in situ to streams adjacent to sewage treatment plants JO - BMC Bioinformatics SP - S11 VL - 10 IS - 11 AB - Environmental monitoring for pharmaceuticals and endocrine disruptors in the aquatic environment traditionally employs a variety of methods including analytical chemistry, as well as a variety of histological and biochemical endpoints that correlate with the fish fitness. It is now clear that analytical chemistry alone is insufficient to identify aquatic environments that are compromised because these measurements do not identify the biologically available dose. The biological endpoints that are measured are important because they relate to known impairments; however, they are not specific to the contaminants and often focus on only a few known endpoints. These studies can be enhanced by looking more broadly at changes in gene expression, especially if the analysis focuses on biochemical pathways. The present study was designed to obtain additional information for well-characterized sites adjacent to sewage treatment plants in MN that are thought to be impacted by endocrine disruptors. SN - 1471-2105 UR - https://doi.org/10.1186/1471-2105-10-S11-S11 DO - 10.1186/1471-2105-10-S11-S11 ID - Garcia-Reyero2009 ER -