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Table 3 Significant important genes distinguishing genotoxicity and cytotoxicity

From: Graph ranking for exploratory gene data analysis

Gene ID

Gene Name

Description

YGR180C*

RNR4

Ribonucleotide-diphosphate reductase (RNR)

YLR178C*

TFS1

Carboxypeptidase Y inhibitor

YDR001C*

NTH1

Neutral trehalase, degrades trehalose

YJL178C*

ATG27

Type I membrane protein

YMR090W*

 

unkown function

YGL063W

PUS2

Mitochondrial tRNA:pseudouridine synthase

YGR036C

CAX4

Dolichyl pyrophosphate (Dol-P-P) phosphatase

YHL028W

WSC4

ER membrane protein

YIL149C

MLP2

Myosin-like protein associated with the nuclear envelope

  1. Genes selected in this table are capable of discriminating between genotoxic and cytotoxic agents. They behave similarly within group but totally different between groups. Genes with * are over-expressed for genotoxic treatments but down-regulated for cytotoxic components. Genes without * are induced for cytotoxic stress but repressed for genotoxic stress.
  2. Genes with * are over-expressed under treatment of genotoxic stress but under-regulated for cytotoxic stress. Genes without * are induced for cytotoxic but repressed for genotoxic compounds.