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Table 1 A comparison of human pathways in HPD against several common pathway data sources.

From: HPD: an online integrated human pathway database enabling systems biology studies

   BioCarta1 HumanCyc2 KEGG3 Reactome4 PID5 Protein Lounge6 HPD
Quality Scope of Content Metabolic and signaling pathways Metabolic Pathways Metabolic, Regulatory, signaling, disease and drug pathways Metabolic, signaling and regulatory pathways Signaling and regulatory pathways Metabolic, signaling and regulatory pathways Metabolic, signaling and regulatory pathways
  Curation Type Manual Manual and Computational Prediction Manual Manual Manual Manual Integrated from Manually curated database
Coverage Human Pathways 354 327 205 960 87 427 999
  Events > 3000 > 1500 4149 3203 5232 NA 16271
Functionality Related Pathways No No Yes No No No Yes
  Multiple Protein Search No No No No Yes No Yes
  Pathway-Protein Association Table No No No No No No Yes
  Pathway-Pathway Similarity Network No No No No No No Yes
  1. 1 Data from http://www.biocarta.com (as of April 2009)
  2. 2Data from http://humancyc.org/ (as of October 2008)
  3. 3Data from http://www.genome.jp/kegg/ (as of March 2009)
  4. 4Data from http://www.reactome.org (as of April 2009)
  5. 5Data from http://pid.nci.nih.gov/ (as of April 2009)
  6. 6Data from http://www.proteinlounge.com (Commercial Version, as of April 2009)
  7. ** The count of HPD pathways has 39 pathways more than reactome since HPD utilizes 2004 Reactome (version 22 release). The next version would include the recent version from Reactome