Traditional depiction of multiple sequence alignment. A depiction of the multiple sequence alignment of 3 DNA methyltransferase (Trdmt1) proteins from different organisms: Human [GenBank:NP_004403], cow [GenBank:NP_861528], and mouse [GenBank:NP_034197]. Strength of alignment is indicated by asterisks, colons, periods, or spaces from strongest to weakest. Clustal  was used to generate the image. In the image, color indicates physico-chemical properties of the amino-acid, and the symbols below each position in the sequence indicate the amount of conservation ('*': Exact, ':': Conserved Substitution, '.': Semi-conserved substitution).