Figure 4

Hierarchical clustering of the 41 PKA pathway-encoding genes in transformed samples. Two-way (gene, column and cell line, row) hierarchical clustering (see Methods) of the profiles from the NCI60 collection only. Normalized expression is colour-coded from green (poor expression) to red (strong expression). The distance function is based on Pearson correlation and complete linkage clustering. The name of each gene is colour-coded according to the family to which it belongs. Legends for expression, condition, gene family and tissue of origin are shown on the right of the dendrogram. The data have been organized on the basis of the tissue of origin of the cancer (Tissue), the specific oncogenic mutations identified in each cell line (Mutation), the putative altered pathway by the specific mutations (Pathway) and the gene family.