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Figure 5 | BMC Bioinformatics

Figure 5

From: Data recovery and integration from public databases uncovers transformation-specific transcriptional downregulation of cAMP-PKA pathway-encoding genes

Figure 5

TFBS identification by using the enrichment as parameter. (A) The panel shows for each TFBS, recognized as relevant (present in ≥ 70% of the promoters of 41 PKA pathway-encoding genes) the percentage of promoters in our collection that contain the motif as compared to Matrix Family Library on vertebrates. This percentage has been calculated by dividing the total number of promoters containing the motif (S) by the total number of promoters (T). Color-coding scheme on the right of the panel. (B) Schematic representation of the TFBSs (color-coded as shown on the right of the panel) identified in the promoters of the 15 subgroups described in the text and in Figure 3. Each cartoon represents the promoter structure resulting from the average of the TFBS identified in ≥ 70% of the gene promoters for each subgroup. The asterisks on the bottom of the cartoon indicate the over-represented TFBS, as scored in panel A, for all the 41 PKA pathway-encoding genes.

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