Data recovery and integration from public databases uncovers transformation-specific transcriptional downregulation of cAMP-PKA pathway-encoding genes

Table 4 Correlation between PKA related gene patterns and tissues

Class	Normal	Transformed
I	Kidney 3/3	Breast 2/8 Lung 1/9 CNS 1/6 Kidney 2/8 Prostate 1/2 Ovary 2/6
II		Colon 6/7 Prostate 1/2 Lung 1/9 Hemopoietic 6/7
III	Ovary 3/3	Ovary 4/6 Breast 1/8 Kidney 5/8
IV	Colon 4/4 Hemopoietic 4/4	Breast 2/8 Kidney 1/8 CNS 4/6 Lung 2/9 Skin 1/8
V		Breast 3/8 CNS 1/6 Colon 1/7 Skin 7/8 Lung 4/9
VI	CNS 2/2 Prostate 3/3 Lung 2/2	Lung 1/9

Six different classes, corresponding to the main arms of the dendrogram derived from clustering according to "Tissue and cell line", were identified. The number on the right of each tissue represents the number of samples belonging to a class as compared to the total sample analyzed.

ISSN: 1471-2105