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Table 2 Top-ten promiscuous domains in the three Kingdoms Numbers in parenthesis is the weight scores of Pfam domains.

From: Protein comparison at the domain architecture level

Order

Eukaryote

Bacteria

Archaea

1

Ank (0.19)

TPR_2 (0.41)

Fer4 (0.86)

2

WD40 (0.24)

Response_reg (0.45)

PKD (1.71)

3

zf-C2H2 (0.3)

ABC_tran (0.47)

CBS (1.82)

4

zf-C3HC4 (0.3)

Acetyltransf_1 (0.50)

Radical_SAM (2.15)

5

RRM_1 (0.41)

Fer4 (0.62)

AAA (2.50)

6

7tm_1 (0.44)

TPR_1 (0.63)

Response_reg (2.79)

7

PH (0.46)

HATPase_c (0.64)

HATPase_c (2.81)

8

efhand (0.46)

fn3 (0.73)

HTH_5 (2.84)

9

EGF (0.48)

HTH_3 (0.74)

PAS (3.08)

10

MFS_1 (0.53)

HisKA (0.75)

TPR_2 (3.15)