Identifying hypothetical genetic influences on complex disease phenotypes

BMC Bioinformatics

Table 1 Validation results for positive controls. Results of validation experiments on positive controls from previous genetic studies. The p-values are from the original study, and the numeric column labels refer to the delta from the loci in KBP.

Phenotype	Locus	Locus	P-Value	1	100	250	500
Breast Cancer⁷	XPD	IL10	0.007	✔	✔	✔	✔
Breast Cancer⁷	GSTP1	COMT	0.007	✔	✔
Breast Cancer⁷	COMT	CCND1	0.014	✔
Breast Cancer⁷	BARD1	XPD	0.014		✔
Breast Cancer⁷	CYP17	GADD45g	0.062
Breast Cancer⁷	TNFa	p27	0.079	✔
Breast Cancer⁷	BARD1	ESR1	N/A
Breast Cancer⁷	BARD1	p27	N/A
Breast Cancer⁸	GSTM1	CYP2e1	0.05	✔	✔	✔
Osteoporosis⁹	NR3C1	ESR2	0.047	✔
Osteoporosis⁹	NR3C1	HDC	N/A
Osteoporosis⁹	RANK	TNFR2	N/A		✔
Anorexia Nervosa¹⁰	MAOA	SLC6A2	0.019	✔	✔	✔	✔
Colorectal Cancer¹¹	ALDH2	ADH1B	0.001	✔	✔	✔	✔
Asthma¹²	CD14	IL4Ra	0.001	✔
Neural Tube Defect¹³	CbetaS	MTHFR	0.007	✔	✔	✔
Neural Tube Defect¹³	MTRR	MTHFR	0.003	✔	✔		✔
Neural Tube Defect¹³	MTRR	FOLH1	0.004	✔

ISSN: 1471-2105