Table 1 Top 10 genes having variants associated with the greatest number of diseases, as identified from the NIH Genetic Association Database.
From: The "etiome": identification and clustering of human disease etiological factors
Gene Symbol and Name | Count of Distinct Associated Diseases |
|---|---|
ACE (angiotensin I converting enzyme) | 100 |
TNF (tumor necrosis factor alpha) | 88 |
TP53 (tumor protein 53) | 73 |
VDR (vitamin D receptor) | 66 |
HLA.DRB1 | 59 |
APOE (apolipoprotein E) | 56 |
NOS3 (nitric oxide synthase 3) | 54 |
MTHRF (methylenetetrahydrofolate redutase) | 53 |
HLA.DQB1 | 46 |
IL10 (interleukin 10) | 46 |