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Table 1 Top 10 genes having variants associated with the greatest number of diseases, as identified from the NIH Genetic Association Database.

From: The "etiome": identification and clustering of human disease etiological factors

Gene Symbol and Name Count of Distinct Associated Diseases
ACE (angiotensin I converting enzyme) 100
TNF (tumor necrosis factor alpha) 88
TP53 (tumor protein 53) 73
VDR (vitamin D receptor) 66
HLA.DRB1 59
APOE (apolipoprotein E) 56
NOS3 (nitric oxide synthase 3) 54
MTHRF (methylenetetrahydrofolate redutase) 53
HLA.DQB1 46
IL10 (interleukin 10) 46