Figure 1
From: Identifying promoter features of co-regulated genes with similar network motifs
The PhoP/PhoQ system employs a variety of network motifs to regulate gene transcription. (A) In the single-input module, PhoP as a single transcription factor regulates a set of genes (i.e. mgtA, phoP and pmrD). (B) In the multi-input module, two or more transcription factors (e.g., PhoP and RcsB) regulate a target gene (i.e. ugd). (C) In the bi-fan module, a set of genes (i.e. pmrD and yrbL) are each regulated by a combination of transcription factors (i.e. PhoP and PmrA). (D) In the chained motif, genes are regulated in an ordered cascade. (E) In the feedforward loop, a transcription factor (i.e. PhoP) regulates the expression of a second transcription factor (i.e. YhiW), and both jointly regulate one or more genes (i.e. hdeA/D).