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Table 2 Overlap between the different knowledgebases and the literature extracted mutations

From: Extraction of human kinase mutations from literature, databases and genotyping studies

Literature derived mutations and overlap with knowledgebases

Knowledgebase (KB)

Total Mutations in KB [weight]

Abstract

Full Text

Combined (Abs+FT)

SwissProt – all

710 [56.13%]

134 (18.87%)

328 (46.20%)

365 (51.41%)

SwissProt – natural variant

459 [36.28%]

99 (21.57%)

196 (42.70%)

230 (50.11%)

SwissProt – mutagenesis

251 [19.84%]

35 (13.94%)

132 (52.59%)

135 (53.78%)

SAAPdb – all

610 [48.22%]

65 (10.66%)

106 (17.38%)

125 (20.49%)

SAAPdb – pathogenic deviations

323 [25.53%]

64 (19.81%)

105 (32.51%)

123 (38.08%)

SAAPdb – neutral

287 [22.69%]

1 (0.35%)

1 (0.35%)

2 (0.70%)

Greenman & Wood

254 [20.08%]

4 (1.57%)

12 (4.72%)

13 (5.12%)

Greenman & Wood – driver

119 [9.04%]

3 (2.52%)

9 (7.56%)

9 (7.56%)

Greenman & Wood – passenger

135 [10.67%]

1 (0.74%)

3 (2.22%)

4 (2.96%)

COSMIC

200 [15.81%]

4 (2.00%)

11 (5.50%)

12 (6.00%)

KinMutBase

83 [6.56%]

32 (38.55%)

32 (38.55%)

43 (51.81%)

All Databases

1265

148 (11.70%)

354 (27.98%)

399 (31.54%)