From: Extraction of human kinase mutations from literature, databases and genotyping studies
Literature derived mutations and overlap with knowledgebases | ||||
---|---|---|---|---|
Knowledgebase (KB) | Total Mutations in KB [weight] | Abstract | Full Text | Combined (Abs+FT) |
SwissProt – all | 710 [56.13%] | 134 (18.87%) | 328 (46.20%) | 365 (51.41%) |
SwissProt – natural variant | 459 [36.28%] | 99 (21.57%) | 196 (42.70%) | 230 (50.11%) |
SwissProt – mutagenesis | 251 [19.84%] | 35 (13.94%) | 132 (52.59%) | 135 (53.78%) |
SAAPdb – all | 610 [48.22%] | 65 (10.66%) | 106 (17.38%) | 125 (20.49%) |
SAAPdb – pathogenic deviations | 323 [25.53%] | 64 (19.81%) | 105 (32.51%) | 123 (38.08%) |
SAAPdb – neutral | 287 [22.69%] | 1 (0.35%) | 1 (0.35%) | 2 (0.70%) |
Greenman & Wood | 254 [20.08%] | 4 (1.57%) | 12 (4.72%) | 13 (5.12%) |
Greenman & Wood – driver | 119 [9.04%] | 3 (2.52%) | 9 (7.56%) | 9 (7.56%) |
Greenman & Wood – passenger | 135 [10.67%] | 1 (0.74%) | 3 (2.22%) | 4 (2.96%) |
COSMIC | 200 [15.81%] | 4 (2.00%) | 11 (5.50%) | 12 (6.00%) |
KinMutBase | 83 [6.56%] | 32 (38.55%) | 32 (38.55%) | 43 (51.81%) |
All Databases | 1265 | 148 (11.70%) | 354 (27.98%) | 399 (31.54%) |