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Table 2 Overlap between the different knowledgebases and the literature extracted mutations

From: Extraction of human kinase mutations from literature, databases and genotyping studies

Literature derived mutations and overlap with knowledgebases
Knowledgebase (KB) Total Mutations in KB [weight] Abstract Full Text Combined (Abs+FT)
SwissProt – all 710 [56.13%] 134 (18.87%) 328 (46.20%) 365 (51.41%)
SwissProt – natural variant 459 [36.28%] 99 (21.57%) 196 (42.70%) 230 (50.11%)
SwissProt – mutagenesis 251 [19.84%] 35 (13.94%) 132 (52.59%) 135 (53.78%)
SAAPdb – all 610 [48.22%] 65 (10.66%) 106 (17.38%) 125 (20.49%)
SAAPdb – pathogenic deviations 323 [25.53%] 64 (19.81%) 105 (32.51%) 123 (38.08%)
SAAPdb – neutral 287 [22.69%] 1 (0.35%) 1 (0.35%) 2 (0.70%)
Greenman & Wood 254 [20.08%] 4 (1.57%) 12 (4.72%) 13 (5.12%)
Greenman & Wood – driver 119 [9.04%] 3 (2.52%) 9 (7.56%) 9 (7.56%)
Greenman & Wood – passenger 135 [10.67%] 1 (0.74%) 3 (2.22%) 4 (2.96%)
COSMIC 200 [15.81%] 4 (2.00%) 11 (5.50%) 12 (6.00%)
KinMutBase 83 [6.56%] 32 (38.55%) 32 (38.55%) 43 (51.81%)
All Databases 1265 148 (11.70%) 354 (27.98%) 399 (31.54%)