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Figure 8 | BMC Bioinformatics

Figure 8

From: Pairwise and higher-order correlations among drug-resistance mutations in HIV-1 subtype B protease

Figure 8

Predicted vs observed probabilities for a triple mutant for all triples of drug-associated positions in the HIV protease using sequences from the PI0 (A) and PI2+ (B) cohorts. Mutational states that were unobserved in the database and would have an observed probability maximum likelihood estimate of zero are not shown. The dots correspond to the best fit pair-term model, and the red lines of slope 1 correspond to the perfect agreement of the predicted probabilities with those observed, which would be obtained if the three-body interactions were included.

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