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Table 1 The 10 triples in HIV protease from the PI2+ cohort sequences with the largest (A, B, C) values (all three-body interactions are significant with p ≪ 10-6).

From: Pairwise and higher-order correlations among drug-resistance mutations in HIV-1 subtype B protease

residue triple

(A, B, C)

I multi (A, B, C)

46-54-90

0.03219

0.20170

46-71-90

0.03101

0.29041

46-82-90

0.03085

0.20640

82-84-90

0.02570

0.13237

10-46-90

0.02445

0.31475

46-71-73

0.02195

0.16610

36-46-90

0.02191

0.15949

46-54-71

0.02072

0.23595

46-77-82

0.02068

0.14573

20-82-90

0.02030

0.14661