Table 1 Node attribute description

UniProtId

UniProt identifier

entrezGeneId

Entrez Gene identifier

mutagenesis

List of the mutagenesis information:

contains the amino acid exchange, the sequence position and the textual phenotypic description from UniProt

polymorphism

List of the natural variant/polymorphism information:

contains the amino acid exchange, the sequence position, the textual phenotypic description from UniProt and if available a MIM id and the textual description of the disease association; if at the same position mutagenesis data is also available, this data is listed as a sub-list of the polymorphism

OMIM

Disease name associated with the natural variant

DbSNP

dbSNP identifier

GObiolProcess

List of GO biological process terms that are associated to the natural variant or mutant

GObiolProcessId

List of GO biological process identifiers that are associated to the natural variant or mutant

GOmolFunction

List of GO molecular function terms that are associated to the natural variant or mutant

GOmolFunctionId

List of GO molecular function identifiers that are associated to the natural variant or mutant

GOcellComponent

List of GO cellular component terms that are associated to the natural variant or mutant

GOcellComponentId

List of GO cellular component identifiers that are associated to the natural variant or mutant

extUniProtIds

List of UniProt identifiers that are associated to the natural variant or mutant

mutPolyFlag

Required for the visual styles

1: only mutagenesis information available

2: only polymorphism information available

3: mutagenesis and polymorphism information available but not at the same position

4: mutagenesis and polymorphism information available at the same position