Figure 1From: Using structural bioinformatics to investigate the impact of non synonymous SNPs and disease mutations: scope and limitationsDistributions for the major structural criteria in the disease and polymorphism datasets. White = disease mutations, grey = polymorphisms. A. Stability difference as calculated by the FoldX force field (in kcal.mol-1). B. Difference in aggregation propensity as calculated by the Tango algorithm. Values close to neutral changes (in the range [-50, 50]) are left out for display purposes. C. Distribution of degree of burial of the amino acid substitution site.Back to article page