Figure 2

Tanimoto coefficients vs. Loss in prediction accuracy. Each data point represents a pair of compounds, where the x-coordinate is the Tanimoto coefficient (calculated by Chemcpp), and the y-coordinate is the loss in prediction accuracy when a substitute drug's sensitivity profile is used in response prediction. For each interval of Tanimoto coefficients, the 99% confidence intervals (for loss in accuracy values) are shown as red bars, with the number of pairs of compounds at each interval indicated.